Read PLR Articles Directory Federated States of Micronesia: measles, mumps, rubella, and varicella virus vaccine live Subcutaneous

MEE-zuls VYE-rus VAX-een, lyve, mumps VYE-rus VAX-een, lyve, roo-BELL-a VYE-rus VAX-een, lyve, var-i-SEL-a VYE-rus VAX-een

Commonly used brand name(s)

In the U.S.

ProQuad

Available Dosage Forms:

Powder for Solution

Powder for Suspension

Therapeutic Class: Vaccine

Uses For measles, mumps, rubella, and varicella virus vaccine live

Measles, mumps, rubella, and varicella virus vaccine (live) is an active immunizing agent that is given to protect against infections caused by measles (rubeola), mumps, rubella (German measles), and varicella (chickenpox) viruses. The combination vaccine works by causing the body to produce its own protection (antibodies) against these diseases.

Measles (also known as coughing measles, hard measles, morbilli, red measles, rubeola, and 10-day measles) is an infection that is easily spread from one person to another. Infection with measles can cause serious problems, such as stomach problems, pneumonia, ear infections, sinus problems, convulsions (seizures), brain damage, and possibly death. The risk of serious complications and death is greater for adults and infants than for children and teenagers.

Mumps is an infection that can cause serious problems, such as encephalitis and meningitis, which affect the brain. In addition, teenage boys and men are very susceptible to a condition called orchitis, which causes pain and swelling in the testicles and scrotum, and in rare cases, sterility. Also, mumps infection can cause spontaneous abortion (miscarriage) in women during the first 3 months of pregnancy.

Rubella (also known as German measles) is a serious infection that causes miscarriages, stillbirths, or birth defects in unborn babies when pregnant women get the disease.

Varicella (commonly known as chickenpox) is an infection that is easily spread from one person to another. Chickenpox is usually a mild infection but sometimes it can cause serious problems, such as pneumonia, inflammation of the brain, and a rare disease called Reye's syndrome.

Immunization against measles, mumps, german measles, and chickenpox is recommended for children 12 months to 12 years of age who has not had these diseases. Immunization against these diseases is not recommended for infants younger than 12 months of age and for children 13 years of age and older.

This vaccine is to be administered only by or under the supervision of your child’s doctor or other authorized healthcare professional.

Before Using measles, mumps, rubella, and varicella virus vaccine live

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to measles, mumps, rubella, and varicella virus vaccine live or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of measles, mumps, rubella, and varicella virus vaccine in children 12 months to 12 years of age. However, this vaccine is not recommended for infants younger than 12 months of age and for children 13 years of age and older.

Geriatric

This vaccine is not recommended for use in adult patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this vaccine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this vaccine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aclarubicin

Acyclovir

Adalimumab

Aldesleukin

Alemtuzumab

Altretamine

Amonafide

Amsacrine

Asparaginase

Aspirin

Azacitidine

Azathioprine

Benorilate

Bleomycin

Broxuridine

Busulfan

Capecitabine

Carboplatin

Carmustine

Certolizumab Pegol

Chlorambucil

Choline Magnesium Trisalicylate

Cisplatin

Cladribine

Cyclophosphamide

Cytarabine

Cytarabine Liposome

Dacarbazine

Dactinomycin

Daunorubicin

Daunorubicin Citrate Liposome

Decitabine

Docetaxel

Doxifluridine

Doxorubicin Hydrochloride

Doxorubicin Hydrochloride Liposome

Edatrexate

Eflornithine

Epirubicin

Estramustine

Etanercept

Etoposide

Everolimus

Fingolimod

Floxuridine

Fludarabine

Fluorouracil

Fotemustine

Gallium Nitrate

Gemcitabine

Golimumab

Hydroxyurea

Idarubicin

Ifosfamide

Irinotecan

Lomustine

Mechlorethamine

Melphalan

Meningococcal Vaccine

Mercaptopurine

Mesalamine

Methotrexate

Mitolactol

Mitomycin

Mitotane

Mitoxantrone

Mycophenolic Acid

Olsalazine

Oxaliplatin

Paclitaxel

Pegaspargase

Pentostatin

Pipobroman

Pirarubicin

Plicamycin

Pneumococcal Vaccine Polyvalent

Procarbazine

Raltitrexed

Rilonacept

Rituximab

Salicylamide

Salicylic Acid

Salsalate

Sirolimus

Sodium Salicylate

Sodium Thiosalicylate

Streptozocin

Tacrolimus

Teceleukin

Tegafur

Temsirolimus

Teniposide

Thioguanine

Thiotepa

Topotecan

Treosulfan

Trimetrexate

Trofosfamide

Trolamine Salicylate

Uracil Mustard

Ustekinumab

Vinblastine

Vincristine

Vincristine Liposome

Vindesine

Vinorelbine

Receiving this vaccine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abatacept

Leflunomide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of measles, mumps, rubella, and varicella virus vaccine live

A nurse or other trained health professional will give your child this vaccine. This vaccine is given as a shot under your skin (usually in the upper arms or thighs).

Your child should receive one shot of the vaccine at 12 to 15 months of age and possibly a second shot at 4 to 6 years of age.

Your child may receive certain other vaccines at the same time as this one, but in a different body area.

You should receive a patient information sheet about all of the vaccines your child receives. Make sure you understand all of the information that is given to you.

It is important to receive this vaccine at the proper time. If your child misses a scheduled shot, call your child's doctor to make another appointment as soon as possible.

Precautions While Using measles, mumps, rubella, and varicella virus vaccine live

It is very important that your child return to your doctor’s office at the right time if your child needs a second dose of the vaccine. Be sure to notify your doctor of any side effects that occur after your child receive this vaccine.

Do not become pregnant for 3 months after receiving this vaccine without first checking with your doctor. There is a chance that this vaccine may cause problems during pregnancy. If you think you have become pregnant, tell your doctor right away. Your doctor may want you to join a pregnancy registry for patients receiving this vaccine.

Children who have received this vaccine have developed a fever and in some cases a fever with seizures. Talk with your child's doctor if you have concerns about this.

Your child should avoid close contact with people at high risk for catching the varicella virus for 6 weeks after receiving this vaccine. People who are at risk for catching the virus are pregnant women, newborn babies, and anyone who has a weak immune system that keeps them from fighting infections.

Tell your doctor that you have received this vaccine:

If you are to receive blood transfusions or other blood products within 3 months of receiving this vaccine.

If you are to receive varicella-zoster immune globulin (VZIG) or other immune globulins within 3 to 5 months after receiving this vaccine.

If you are to have a tuberculin skin test within 4 to 6 weeks after receiving this vaccine.

If you are to receive any other live virus vaccines within 1 or 3 months of receiving this vaccine.

Do not take aspirin or medicines that contain aspirin (such as cold medicines) for 6 weeks after receiving this vaccine. Carefully check the label of any pain, headache, or cold medicine you give to your child to be sure it does not contain aspirin or salicylic acid.

This vaccine contains albumin, which comes from human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the manufacture of these medicines. Although the risk is low, talk with your child's doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

measles, mumps, rubella, and varicella virus vaccine live Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Fever over 39 °C (102 °F)

Less common

Body aches or pain

chills

cough

ear congestion

fever

headache

loss of voice

nasal congestion

rash that looks like chickenpox or measles

runny nose

sneezing

sore throat

unusual tiredness or weakness

Incidence not known

Agitation

back pain, sudden and severe

bleeding gums

blistering, peeling, or loosening of the skin

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

bloody nose

bloody or black, tarry stools

blurred vision

burning or stinging of the skin

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain

coma

confusion

cough or hoarseness

cough producing mucus

diarrhea

difficulty with breathing

difficulty with swallowing

dizziness

drowsiness

fainting

fast heartbeat

general feeling of discomfort or illness

hallucinations

hives

inability to move the arms and legs

inability to speak

irritability

itching, pain, redness, swelling, tenderness, or warmth on the skin

joint or muscle pain

large, flat, blue, or purplish patches in the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of appetite

lower back or side pain

mood or mental changes

muscle aches and pains

muscle weakness, sudden and progressing

nausea

noisy breathing

numbness, tingling, pain, or weakness in the hands or feet

pain, numbness, or tingling of the hands, arms, legs, or feet

pain, tenderness, or swelling in the testicles and scrotum

painful blisters on the trunk of the body

painful cold sores or blisters on the lips, nose, eyes, or genitals

painful knees and ankles

painful or difficult urination

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised red swellings on the skin, buttocks, legs, or ankles

rapid weight gain

red skin lesions, often with a purple center

red, irritated eyes

seizures

severe or sudden headache

shakiness and unsteady walk

shakiness in the legs, arms, hands, or feet

shivering

shortness of breath

skin rash

skin rash on the face, scalp, or stomach

slurred speech

sores, ulcers, or white spots on the lips or in the mouth

stiff neck or back

stomach pain

sudden numbness and weakness in the arms and legs

sweating

swelling or puffiness of the face

swollen or painful glands

swollen, painful, or tender lymph glands in the neck, armpit, or groin

swollen, painful, or tender lymph glands on the side of the face or neck

temporary blindness

tenderness

thickening of bronchial secretions

tightness in the chest

tingling of the hands or feet

trembling or shaking of the hands or feet

trouble sleeping

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

unusual weight gain or loss

vomiting

warmth on the skin

weakness in the arm or leg on one side of the body, sudden and severe

weakness of the muscles in your face

wheezing

white patches in the mouth or throat or on the tongue

white patches with diaper rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Incidence not known

Abnormal dreams

blindness

bloated

blue-yellow color blindness

deafness

decreased vision

difficulty with moving

double vision

ear pain

excess air or gas in the stomach or intestines

eye pain

full feeling

irritation and swelling of the eyelids

lack of feeling or emotion

muscle or bone pain

muscle pain or stiffness

nervousness

pain and swelling in the scrotum

pain in the hip, leg, or neck

pain or tenderness around the eyes and cheekbones

passing gas

red rash with watery, yellow-colored, or pus filled blisters

thick yellow to honey-colored crusts

uncaring

unusually deep sleep

unusually long duration of sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

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Friday, September 2, 2016

measles, mumps, rubella, and varicella virus vaccine live Subcutaneous